Genome Editing Verification
With the development of CRISPR/Cas9 system, genome editing has become efficient and programmable, leading to promising translational studies and clinical trials for both genetic and non-genetic diseases. However, a major concern in the applications of the CRISPR/Cas9 system is its off-target effects, namely the deposition of unexpected, unwanted, or even adverse alterations to the genome. Analysis of off-target editing is an important aspect of the development of safe nuclease-based genome editing therapeutics. RedyBio offers efficient, and economical assay to profile and verify off-target genome editing.
Workflow
Step 1: Genomic DNA Extraction from Transfection Cells
Step 2: Library Preparation
Step 3: NGS Sequencing
Step 4: Data Analysis and Off-target Summary
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