In Vivo CAR-T Development

In Vivo CAR-T Cell Therapy Services

Chimeric Antigen Receptor T cell (CAR-T) therapy has transformed the treatment landscape for cancer. Traditional ex vivo CAR-T approaches, while effective, are limited by high costs, long manufacturing timelines, and accessibility issues.

In vivo CAR-T is the next evolution—offering a transformative approach where CAR-T cells are generated directly inside the patient’s body. This eliminates the need for cell collection and laboratory modification, simplifying treatment and expanding patient access.

In Vivo CAR-T Cell Therapy Services
Key Advantages of In Vivo CAR-T

Key Advantages of In Vivo CAR-T

  • Off-the-shelf therapy – no need for personalized cell manufacturing
  • No lymphodepletion required
  • No risk of graft-versus-host disease (GvHD)
  • Reduced immune rejection of engineered cells
  • High scalability – treat hundreds of patients per production batch
  • Streamlined patient experience – simplified treatment workflow
  • Compatible with multiple cell types – T cells, NK cells, macrophages
  • Lower complexity and cost – bypasses ex vivo processing

Service Offerings

Non-Viral Platforms

  • Lipid Nanoparticle (LNP)–mRNA/Circular RNA
  • LNP–Bridge RNA
  • LNP–Transposon
  • Virus-Like Particles (VLPs)

Viral Platforms

  • Lentiviral Vectors (LV)
  • Adeno-Associated Virus (AAV)

Cell-Specific Targeting

  • CD3⁺ T cells
  • CD4⁺ and CD8⁺ T cell subsets
  • NK cells
  • Macrophages

Platform Enhancements

  • Fusogen mutant screening & discovery – for enhanced gene delivery
  • T cell–specific promoter optimization – to boost selective CAR expression


Case Study

Why Choose RedyBio?

  • Industry-leading expertise in both non-viral (LNP-RNA) and viral CAR delivery systems
  • Deep experience in CAR design and optimization
  • Flexible and scalable platforms tailored to your therapeutic goals
Why Choose RedyBio?

Contact us

  • info@redybio.com
  • (858) 876-8688
  • 6331 Nancy Ridge Dr. Suite A San Diego, CA 92121

Let us work together

Reach out for more information or a quote. Our team is here to assist you with your research needs and inquiries.

Contact Form